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CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS › Beta blocking agents, non-selective
penbutolol
C07AA23
Adult Dosing
- Hypertension: Initial 20 mg once daily; may be increased up to 40-80 mg once daily if needed.
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established.
Indications
- Management of mild to moderate hypertension
Mechanism of Action
- Non-selective beta-adrenergic receptor blocker with intrinsic sympathomimetic activity (ISA), reducing cardiac output and sympathetic outflow.
Contraindications
- Sinus bradycardia
- Second- or third-degree atrioventricular block
- Cardiogenic shock
- Overt cardiac failure
- Hypersensitivity to penbutolol
Adverse Reactions
- Dizziness
- Fatigue
- Headache
- Nausea
- Insomnia
- Bradycardia
Drug Interactions
- Calcium channel blockers (verapamil, diltiazem): Increased risk of bradycardia and AV block.
- Catecholamine-depleting drugs (reserpine): May cause additive hypotension or marked bradycardia.
- Digitalis glycosides: Increased risk of bradycardia and delayed AV conduction.
Curated Content: Needs Vetting Before Put to Clinical Use