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CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS › Beta blocking agents, selective
betaxolol
C07AB05
Forms & Strengths
- Oral tablets: 10 mg, 20 mg
- Ophthalmic solution: 0.5%
Adult Dosing
- Hypertension: Oral 10 mg once daily, may increase to 20 mg daily
- Glaucoma/Ocular Hypertension: Ophthalmic 1 drop in affected eye(s) twice daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Management of hypertension (oral)
- Reduction of intraocular pressure in chronic open-angle glaucoma and ocular hypertension (ophthalmic)
Mechanism of Action
- Selective beta-1 adrenergic receptor blocker
- Lacks intrinsic sympathomimetic activity and membrane-stabilizing activity
- Decreases heart rate, cardiac output, and blood pressure (oral); reduces aqueous humor production (ophthalmic)
Contraindications
- Sinus bradycardia
- Second- or third-degree atrioventricular block
- Overt cardiac failure
- Cardiogenic shock
- Hypersensitivity to betaxolol
Adverse Reactions
- Bradycardia
- Hypotension
- Fatigue
- Dizziness
- Insomnia
- Ophthalmic: transient ocular stinging, blurred vision, lacrimation
Drug Interactions
- Catecholamine-depleting drugs (e.g., reserpine) may produce additive hypotensive and bradycardic effects
- Digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate
- Calcium channel blockers (e.g., verapamil, diltiazem) may increase risk of myocardial depression and bradycardia
- CYP1D6 inhibitors may alter betaxolol plasma concentrations
Curated Content: Needs Vetting Before Put to Clinical Use