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CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS › Beta blocking agents, selective
s-atenolol
C07AB11
Forms & Strengths
- Tablets: 25mg, 50mg, 100mg
- Injectable: 5mg/mL
Adult Dosing
- Hypertension: 25-50mg PO qd, max 100mg
- Angina: 50mg PO qd, max 200mg
- Post-MI: 50mg PO qd, max 200mg
Pediatric Dosing
- Not recommended for children under 12 years
- Hypertension (12-18y): 25-50mg PO qd, max 100mg
Indications
- Hypertension
- Angina pectoris
- Post-myocardial infarction
- Cardiac arrhythmias
Mechanism of Action
- Beta-1 adrenergic receptor antagonist
- Decreases heart rate and myocardial contractility
- Reduces cardiac output and blood pressure
Contraindications
- Cardiogenic shock
- Sick sinus syndrome
- AST or ALT >2x ULN
- Second- or third-degree AV block
- Bronchial asthma or COPD
- Untreated pheochromocytoma
Adverse Reactions
- Fatigue
- Dizziness
- Headache
- Cold extremities
- Hypotension
- Bronchospasm
- Diarrhea or constipation
Drug Interactions
- Digoxin: increased risk of bradycardia
- Verapamil: increased risk of AV block
- Epinephrine: decreased efficacy
- Clonidine: increased risk of hypertension
- MAOIs: increased risk of hypotension
Curated Content: Needs Vetting Before Put to Clinical Use