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CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS › Beta blocking agents, selective
talinolol
C07AB13
Forms & Strengths
- Oral tablets 50 mg
- Oral tablets 100 mg
Adult Dosing
- Hypertension: 50 mg to 100 mg orally once daily, may increase up to 300 mg daily if needed
- Angina pectoris: 50 mg to 100 mg orally once to twice daily
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Hypertension
- Angina pectoris
Mechanism of Action
- Cardioselective beta-1 adrenergic receptor antagonist
- Reduces heart rate, myocardial contractility, and cardiac output
- Substrate for P-glycoprotein efflux transporter in the intestine
Contraindications
- Second- or third-degree atrioventricular block without a pacemaker
- Decompensated heart failure
- Cardiogenic shock
- Severe bradycardia (<50 bpm)
- Severe hypotension
- Hypersensitivity to talinolol
Adverse Reactions
- Bradycardia
- Fatigue
- Dizziness
- Hypotension
- Cold extremities
- Sleep disturbances
- Gastrointestinal upset
Drug Interactions
- P-glycoprotein inhibitors (e.g., verapamil, amiodarone) significantly increase talinolol plasma concentrations and risk of toxicity
- Negative chronotropes (e.g., digoxin, diltiazem) increase risk of bradycardia and conduction abnormalities
- Insulin and oral hypoglycemics may have their hypoglycemic effects masked by beta-blockade
- Non-steroidal anti-inflammatory drugs (NSAIDs) may decrease the antihypertensive effect of beta-blockers
Curated Content: Needs Vetting Before Put to Clinical Use