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CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS AND THIAZIDES › Beta blocking agents, non-selective, and thiazides
oxprenolol and thiazides
C07BA02
Forms & Strengths
- Tablets: 80mg oxprenolol + 25mg chlorthalidone
- Tablets: 160mg oxprenolol + 25mg chlorthalidone
- Capsules: 160mg oxprenolol + 25mg hydrochlorothiazide
Adult Dosing
- Hypertension: 1-2 tablets/capsules daily
- Angina pectoris: 1-2 tablets/capsules daily
- Initial dose: 80-160mg oxprenolol + 25mg thiazide
- Maximum dose: 320mg oxprenolol + 50mg thiazide
Pediatric Dosing
- Not recommended for children under 12 years old
- Dosage adjustments may be necessary for adolescents
Indications
- Hypertension
- Angina pectoris
- Arrhythmias
- Prophylaxis of myocardial infarction
Mechanism of Action
- Oxprenolol: non-selective beta-blocker
- Thiazides: inhibit sodium reabsorption in the kidneys
- Reduces heart rate, contractility, and cardiac output
- Increases diuresis, reduces peripheral resistance
Contraindications
- Asthma
- Chronic obstructive pulmonary disease (COPD)
- Uncompensated heart failure
- Cardiogenic shock
- Severe bradycardia
- Hypersensitivity to thiazides or beta-blockers
Adverse Reactions
- Bradycardia
- Hypotension
- Fatigue
- Dizziness
- Headache
- Nausea
- Diarrhea
- Bronchospasm
Drug Interactions
- Verapamil: increased risk of bradycardia
- Digoxin: increased risk of digitalis toxicity
- Clonidine: increased risk of hypotension
- MAOIs: increased risk of hypotension
- Antiarrhythmics: increased risk of cardiac conduction disturbances
Curated Content: Needs Vetting Before Put to Clinical Use