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CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS AND THIAZIDES › Beta blocking agents, selective, and thiazides
acebutolol and thiazides
C07BB04
Forms & Strengths
- Tablets: 400mg acebutolol + 5mg hydrochlorothiazide
- Tablets: 400mg acebutolol + 12.5mg hydrochlorothiazide
- Tablets: 400mg acebutolol + 25mg hydrochlorothiazide
Adult Dosing
- Initially 400mg acebutolol + 5mg hydrochlorothiazide daily
- Dose may be increased to 800mg acebutolol + 25mg hydrochlorothiazide daily
- Dose titration at 2 week intervals
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use is not recommended in children under 12 years old
Indications
- Hypertension
- Angina pectoris
- Treatment of essential hypertension alone or in combination
Mechanism of Action
- Acebutolol: beta1-selective adrenergic receptor blocker
- Hydrochlorothiazide: thiazide diuretic that inhibits sodium reabsorption
- Together, reduce cardiac output and peripheral resistance, and increase sodium and water excretion
Contraindications
- Hypersensitivity to acebutolol, thiazides, or sulfonamides
- Cardiogenic shock
- Heart block greater than first degree
- Severe bradycardia
Adverse Reactions
- Dizziness
- Headache
- Fatigue
- Nausea and vomiting
- Hypotension
- Bradycardia
- Electrolyte imbalance
Drug Interactions
- Verapamil, diltiazem: increase risk of AV block
- Clonidine: increase risk of bradycardia and hypotension
- NSAIDs: decrease antihypertensive effect of thiazides
- Lithium: decrease renal clearance of lithium
Curated Content: Needs Vetting Before Put to Clinical Use