← Search & browse all drugs
CARDIOVASCULAR SYSTEM › BETA BLOCKING AGENTS › BETA BLOCKING AGENTS, OTHER COMBINATIONS › Beta blocking agents and calcium channel blockers
metoprolol and amlodipine
C07FB13
Forms & Strengths
- Tablets: 2.5mg/5mg, 5mg/5mg, 5mg/10mg metoprolol/amlodipine
- Extended-release tablets: 5mg/5mg, 10mg/5mg, 10mg/10mg metoprolol/amlodipine
Adult Dosing
- Initial dose: 2.5mg/5mg to 5mg/5mg once daily
- Titrate every 7-14 days, maximum dose: 10mg/10mg once daily
- Dose adjustments based on blood pressure response
Pediatric Dosing
- Not recommended for pediatric patients under 18 years
- No established safety and efficacy data for pediatric use
Indications
- Hypertension
- Angina pectoris
- Heart failure
Mechanism of Action
- Metoprolol: selective beta-1 adrenergic receptor blocker, reduces heart rate and myocardial contractility
- Amlodipine: dihydropyridine calcium channel blocker, relaxes vascular smooth muscle and reduces blood pressure
Contraindications
- Hypersensitivity to metoprolol, amlodipine, or dihydropyridines
- Cardiogenic shock
- Sick sinus syndrome
- Atrioventricular (AV) block (second or third degree)
- Severe bradycardia
Adverse Reactions
- Dizziness
- Headache
- Fatigue
- Orthostatic hypotension
- Edema
- Bronchospasm
- Worsening of heart failure
Drug Interactions
- Beta-agonists: may reduce efficacy of metoprolol
- Verapamil, diltiazem: may increase risk of AV block
- Clonidine: may increase risk of bradycardia and hypotension
- Digoxin: may increase risk of bradycardia
Curated Content: Needs Vetting Before Put to Clinical Use