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CARDIOVASCULAR SYSTEM › CALCIUM CHANNEL BLOCKERS › SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS › Dihydropyridine derivatives
barnidipine
C08CA12
Forms & Strengths
- Tablets: 5mg, 10mg, 20mg
- Extended-release tablets: 10mg, 20mg
Adult Dosing
- Hypertension: 10mg once daily, titrate to 20mg if needed
- Angina: 5-10mg once daily, titrate to 20mg if needed
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Not recommended for use in children under 18 years
Indications
- Hypertension
- Chronic stable angina pectoris
- Vasospastic angina
Mechanism of Action
- Calcium channel blocker
- Inhibits L-type calcium channels
- Decreases cardiac afterload and myocardial oxygen demand
Contraindications
- Hypersensitivity to barnidipine or other dihydropyridines
- Severe aortic stenosis
- Unstable angina or acute myocardial infarction
Adverse Reactions
- Headache
- Dizziness
- Flushing
- Edema
- Hypotension
Drug Interactions
- Beta blockers: increased risk of hypotension and bradycardia
- Digoxin: increased risk of digoxin toxicity
- CYP3A4 inhibitors: increased barnidipine levels
Curated Content: Needs Vetting Before Put to Clinical Use