← Search & browse all drugs
CARDIOVASCULAR SYSTEM › CALCIUM CHANNEL BLOCKERS › CALCIUM CHANNEL BLOCKERS AND DIURETICS › Calcium channel blockers and diuretics
amlodipine and diuretics
C08GA02
Forms & Strengths
- Tablets: 2.5mg, 5mg, 10mg amlodipine
- Combination with hydrochlorothiazide: 2.5mg/12.5mg, 5mg/12.5mg, 5mg/25mg, 10mg/12.5mg
Adult Dosing
- Hypertension: 2.5mg-10mg daily, alone or in combination
- Angina: 5mg-10mg daily
- Edema: diuretic component dose adjusted based on patient response
Pediatric Dosing
- Not recommended for children under 6 years
- 6-17 years: 2.5mg-5mg daily, adjusted based on response
- Dose titration should occur after 1-2 weeks
Indications
- Hypertension
- Angina pectoris
- Chest pain associated with coronary artery spasm
- Edema
Mechanism of Action
- Amlodipine: calcium channel blocker, inhibits L-type calcium channels
- Diuretic component: increases sodium and chloride excretion, reduces blood volume
Contraindications
- Hypersensitivity to amlodipine, hydrochlorothiazide, or sulfonamides
- Severe aortic stenosis
- Unstable angina, unless vasospastic component is present
Adverse Reactions
- Peripheral edema
- Headache
- Flushing
- Dizziness
- Palpitations
- Fatigue
- Gastrointestinal disturbances
- Hyperkalemia with high doses of amlodipine
Drug Interactions
- Potassium supplements: risk of hyperkalemia
- Cyclosporine: increased amlodipine levels
- Grapefruit juice: increased amlodipine bioavailability
- Other antihypertensive agents: additive effects
Curated Content: Needs Vetting Before Put to Clinical Use