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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, PLAIN › ACE inhibitors, plain
quinapril
C09AA06
Forms & Strengths
- Tablets: 5mg, 10mg, 20mg, 40mg
- Oral solution: 5mg/5mL
Adult Dosing
- Hypertension: 10mg/day, may increase to 20-40mg/day
- Heart failure: 5mg BID, may increase to 20mg BID
Pediatric Dosing
- Not recommended for children under 18 years
- Limited data available for pediatric patients
Indications
- Hypertension
- Heart failure
- Left ventricular dysfunction
Mechanism of Action
- Inhibits angiotensin-converting enzyme (ACE)
- Reduces angiotensin II formation
- Increases bradykinin levels
Contraindications
- Hypersensitivity to quinapril or other ACE inhibitors
- Angioedema
- Bilateral renal artery stenosis
- Unilateral renal artery stenosis in solitary kidney
Adverse Reactions
- Cough
- Dizziness
- Headache
- Fatigue
- Hyperkalemia
- Renal dysfunction
Drug Interactions
- Potassium supplements: increased risk of hyperkalemia
- Diuretics: increased risk of hypotension
- Lithium: increased lithium levels
- NSAIDs: decreased antihypertensive effect
Curated Content: Needs Vetting Before Put to Clinical Use