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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, PLAIN › ACE inhibitors, plain
cilazapril
C09AA08
Forms & Strengths
- Tablets: 1mg, 2.5mg, 5mg
- Oral solution: 1mg/mL
Adult Dosing
- Hypertension: 1-2.5mg once daily, max 5mg
- Heart failure: 0.5-1mg once daily, max 2.5mg
Pediatric Dosing
- Safety and efficacy not established in children under 18
- Not recommended for pediatric use due to limited data
Indications
- Hypertension
- Chronic heart failure
- Asymptomatic left ventricular dysfunction
Mechanism of Action
- Selective inhibition of angiotensin I conversion to angiotensin II
- Decreases peripheral vascular resistance and lowers blood pressure
Contraindications
- Hypersensitivity to cilazapril or other ACE inhibitors
- Pregnancy, especially in 2nd and 3rd trimesters
- Bilateral renal artery stenosis or unilateral stenosis in a solitary kidney
Adverse Reactions
- Cough, headache, dizziness, fatigue
- Hypotension, renal impairment, hyperkalemia
- Angioedema, rash, taste disturbances
Drug Interactions
- Aliskiren, other ACE inhibitors: increased risk of hyperkalemia and hypotension
- Potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: increased risk of lithium toxicity
Curated Content: Needs Vetting Before Put to Clinical Use