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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, PLAIN › ACE inhibitors, plain
delapril
C09AA12
Forms & Strengths
- Tablets: 15mg, 30mg
- Extended release tablets: 30mg
- Combination tablets with indapamide: 15mg/1.25mg, 30mg/2.5mg
Adult Dosing
- Initial dose: 15mg once daily
- Maintenance dose: 30-60mg once daily
- Maximum dose: 60mg once daily
- Dose adjustment for renal impairment: CrCl <30mL/min, reduce dose by 50%
Pediatric Dosing
- Not established for pediatric patients
- Avoid use in children under 18 years due to lack of efficacy and safety data
Indications
- Hypertension
- Congestive heart failure
- Left ventricular dysfunction
- Proteinuric nephropathy
Mechanism of Action
- Inhibits angiotensin-converting enzyme (ACE)
- Blocks conversion of angiotensin I to angiotensin II
- Increases bradykinin levels, promoting vasodilation
- Decreases aldosterone secretion, reducing sodium and water retention
Contraindications
- Hypersensitivity to delapril or other ACE inhibitors
- Pregnancy (2nd and 3rd trimesters)
- Bilateral renal artery stenosis
- Unilateral renal artery stenosis in a transplant patient
Adverse Reactions
- Cough (up to 20%)
- Dizziness (up to 10%)
- Headache (up to 10%)
- Fatigue (up to 5%)
- Hypotension (up to 5%)
- Hyperkalemia (up to 5%)
- Increased creatinine levels (up to 5%)
Drug Interactions
- Potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: increased lithium levels, monitor closely
- NSAIDs: decreased antihypertensive effect, increased risk of renal impairment
- Digoxin: increased digoxin levels, monitor closely
Curated Content: Needs Vetting Before Put to Clinical Use