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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, PLAIN › ACE inhibitors, plain
temocapril
C09AA14
Forms & Strengths
- Tablets: 2mg, 4mg
- Hard gelatin capsules: 1mg, 2mg, 4mg
Adult Dosing
- Hypertension: 2mg orally once daily, titrate to 4mg if necessary
- Heart failure: 1mg orally once daily, titrate to 2mg if necessary
- Renal protection: 2mg orally once daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Not recommended for use in children under 18 years
Indications
- Treatment of essential hypertension
- Treatment of heart failure
- Renal protection in patients with type 2 diabetes and microalbuminuria
Mechanism of Action
- Inhibits angiotensin-converting enzyme (ACE)
- Decreases conversion of angiotensin I to angiotensin II
- Dilates blood vessels, reduces blood pressure
Contraindications
- Hypersensitivity to temocapril or other ACE inhibitors
- History of angioedema related to ACE inhibitor use
- Bilateral renal artery stenosis or unilateral stenosis in a solitary kidney
Adverse Reactions
- Cough (up to 12%)
- Dizziness (up to 8%)
- Headache (up to 6%)
- Hyperkalemia (up to 5%)
- Angioedema (rare)
Drug Interactions
- Potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: increased risk of lithium toxicity
- Nonsteroidal anti-inflammatory drugs (NSAIDs): decreased antihypertensive effect
- Aliskiren: increased risk of hyperkalemia, hypotension, and decreased renal function
Curated Content: Needs Vetting Before Put to Clinical Use