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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, COMBINATIONS › ACE inhibitors and diuretics
zofenopril and diuretics
C09BA15
Forms & Strengths
- Zofenopril 15-60 mg tablet
- Zofenopril 7.5-30 mg tablet
- Zofenopril 28.5 mg+hydrochlorothiazide 12.5-25 mg tablet
Adult Dosing
- Initial dose 7.5-15 mg once daily
- Titrate to 30-60 mg once daily as needed and tolerated
- Maximum dose 60 mg/day
Pediatric Dosing
- Not recommended for children under 6 years
- 6-12 years: 7.5 mg once daily, titrate as needed and tolerated
- Over 12 years: follow adult dosing guidelines
Indications
- Hypertension
- Congestive heart failure
- Acute myocardial infarction
- Left ventricular dysfunction
Mechanism of Action
- Inhibits angiotensin-converting enzyme (ACE)
- Reduces levels of angiotensin II and aldosterone
- Increases bradykinin and prostaglandins, causing vasodilation
- Diuretic component promotes sodium and water excretion
Contraindications
- Hypersensitivity to zofenopril or diuretics
- History of angioedema related to ACE inhibitors
- Bilateral renal artery stenosis or unilateral stenosis in a solitary kidney
- Anuria or acute kidney injury
Adverse Reactions
- Cough
- Dizziness
- Hypotension
- Hyperkalemia
- Renal dysfunction
- Electrolyte disturbances
Drug Interactions
- Potentiates potassium-sparing diuretics
- Reduces efficacy of loop diuretics
- Increases risk of lithium toxicity
- Enhances hypotensive effects of other antihypertensives
- Interacts with NSAIDs, reducing antihypertensive efficacy
Curated Content: Needs Vetting Before Put to Clinical Use