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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, COMBINATIONS › ACE inhibitors and calcium channel blockers
zofenopril and amlodipine
C09BB14
Forms & Strengths
- Zofenopril 15-60mg and Amlodipine 5-10mg tablets
- Fixed-dose combination tablets
- Extended-release formulations
Adult Dosing
- Initial dose: Zofenopril 15-30mg and Amlodipine 5mg once daily
- Titrate every 1-2 weeks, maximum dose: Zofenopril 60mg and Amlodipine 10mg once daily
- Dose adjustments based on blood pressure response
Pediatric Dosing
- Not recommended for pediatric patients under 18 years old
- Safety and efficacy not established in pediatric population
Indications
- Hypertension
- Treatment of patients with Essential Hypertension
- Reduction of cardiovascular risk in patients with hypertension
Mechanism of Action
- Zofenopril: Inhibits ACE, preventing conversion of Angiotensin I to Angiotensin II
- Amlodipine: Blocks L-type calcium channels, relaxing vascular smooth muscle
- Synergistic effect for blood pressure reduction
Contraindications
- Hypersensitivity to Zofenopril, Amlodipine, or other ACE inhibitors and calcium channel blockers
- Angioedema related to previous ACE inhibitor use
- Pregnancy and lactation
Adverse Reactions
- Headache
- Dizziness
- Cough
- Peripheral edema
- Fatigue
- Hyperkalemia
- Renal impairment
Drug Interactions
- NSAIDs: May decrease antihypertensive effect
- Potassium supplements: May increase risk of hyperkalemia
- Lithium: May increase risk of lithium toxicity
- Other antihypertensives: May increase risk of hypotension
Curated Content: Needs Vetting Before Put to Clinical Use