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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, COMBINATIONS › ACE inhibitors, other combinations
perindopril and bisoprolol
C09BX02
Forms & Strengths
- Tablets: perindopril 2mg/bisoprolol 1.25mg
- Tablets: perindopril 4mg/bisoprolol 2.5mg
- Tablets: perindopril 8mg/bisoprolol 5mg
Adult Dosing
- Initial dose: perindopril 2mg/bisoprolol 1.25mg once daily
- Maximum dose: perindopril 8mg/bisoprolol 5mg once daily
- Dose titration at intervals of at least 2 weeks
Pediatric Dosing
- Not recommended for children under 18 years
- No established safety and efficacy in pediatric population
Indications
- Treatment of essential hypertension
- stable, symptomatic heart failure
Mechanism of Action
- Perindopril: ACE inhibitor, reduces angiotensin II levels
- Bisoprolol: beta-1 selective adrenergic receptor blocker, reduces heart rate and contractility
Contraindications
- Hypersensitivity to perindopril or bisoprolol
- History of angioedema related to ACE inhibitors
- Severe bronchial asthma
- Untreated pheochromocytoma
- Second or third degree AV block
Adverse Reactions
- Cough
- Dizziness
- Fatigue
- Headache
- Hypotension
- Nausea
- Palpitations
Drug Interactions
- Digitalis glycosides: increased risk of bradycardia
- Potassium-sparing diuretics: increased risk of hyperkalaemia
- Beta-2 agonists: may reduce the efficacy of bisoprolol
- Allopurinol: increased risk of hypersensitivity reactions
Curated Content: Needs Vetting Before Put to Clinical Use