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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, COMBINATIONS › ACE inhibitors, other combinations
perindopril, bisoprolol and amlodipine
C09BX04
Forms & Strengths
- Perindopril 2.5mg/Bisoprolol 5mg/Amlodipine 5mg tablets
- Perindopril 5mg/Bisoprolol 10mg/Amlodipine 10mg tablets
- Perindopril 10mg/Bisoprolol 10mg/Amlodipine 5mg tablets
Adult Dosing
- Initial dose: Perindopril 2.5mg/Bisoprolol 5mg/Amlodipine 5mg once daily, titrate to 5mg/10mg/10mg or 10mg/10mg/5mg
- Maximum dose: Perindopril 10mg/Bisoprolol 10mg/Amlodipine 10mg once daily
Pediatric Dosing
- Not recommended for children under 18 years
- Limited data available for children, consult expert advice
Indications
- Essential hypertension
- Stable angina
- Chronic heart failure
Mechanism of Action
- Perindopril: ACE inhibition
- Bisoprolol: Beta-1 selective beta-blockade
- Amlodipine: Calcium channel blockade
Contraindications
- Hypersensitivity to perindopril, bisoprolol, or amlodipine
- Severe aortic stenosis
- Unstable angina
- Heart failure with acute pulmonary edema
Adverse Reactions
- Dizziness
- Headache
- Fatigue
- Cough
- Peripheral edema
- Bradycardia
- Hypotension
Drug Interactions
- Digitalis glycosides: increased risk of bradycardia
- Beta-agonists: reduced effect
- Nitrates or other vasodilators: increased risk of hypotension
- Rifampicin: reduced amlodipine levels
Curated Content: Needs Vetting Before Put to Clinical Use