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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN › Angiotensin II receptor blockers (ARBs), plain
losartan
C09CA01
Forms & Strengths
- Tablets: 25mg, 50mg, 100mg
- Oral suspension: 2.5mg/mL
Adult Dosing
- Hypertension: 50mg once daily, may be increased to 100mg once daily
- Diabetic nephropathy: 50mg once daily, may be increased to 100mg once daily
Pediatric Dosing
- Hypertension (6-16 years): 0.7mg/kg once daily, may be increased to 1.4mg/kg once daily
- Not recommended for children under 6 years
Indications
- Hypertension
- Diabetic nephropathy
- Heart failure
- Hypertension with left ventricular hypertrophy
Mechanism of Action
- Angiotensin II receptor antagonist
- Blocks vasoconstrictive and aldosterone-secreting effects of angiotensin II
Contraindications
- Hypersensitivity to losartan or other angiotensin II receptor antagonists
- Concomitant use with aliskiren in patients with diabetes
Adverse Reactions
- Dizziness
- Headache
- Fatigue
- Cough
- Hypotension
- Hyperkalemia
Drug Interactions
- Potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: increased lithium levels
- Warfarin: increased risk of bleeding
- Aliskiren: increased risk of hyperkalemia, hypotension, and renal impairment
Curated Content: Needs Vetting Before Put to Clinical Use