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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), PLAIN › Angiotensin II receptor blockers (ARBs), plain
eprosartan
C09CA02
Forms & Strengths
- Oral tablets: 400 mg
- Oral tablets: 600 mg
Adult Dosing
- Hypertension: Initial 600 mg once daily
- Hypertension maintenance: 400 mg to 800 mg once or twice daily
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Treatment of hypertension
- May be used alone or in combination with other antihypertensive agents
Mechanism of Action
- Angiotensin II receptor blocker (ARB) selective for the AT1 receptor
- Blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II
Contraindications
- Hypersensitivity to eprosartan or any component of the formulation
- Concomitant use with aliskiren in patients with diabetes mellitus
- Pregnancy (direct toxicity to second and third trimesters)
Adverse Reactions
- Dizziness
- Fatigue
- Pharyngitis
- Rhinitis
- Upper respiratory tract infection
- Hyperkalemia
- Hypotension
Drug Interactions
- Lithium: Risk of increased lithium toxicity and serum concentrations
- Potassium-sparing diuretics, potassium supplements, or salt substitutes: Increased risk of hyperkalemia
- NSAIDs: May decrease antihypertensive effect and increase risk of renal impairment
- Dual blockade of the RAS (ACE inhibitors, ARBs, or aliskiren): Increased risk of hypotension, hyperkalemia, and renal dysfunction
Curated Content: Needs Vetting Before Put to Clinical Use