← Search & browse all drugs
CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS › Angiotensin II receptor blockers (ARBs) and diuretics
losartan and diuretics
C09DA01
Forms & Strengths
- Tablets: 50mg, 100mg
- Combination with hydrochlorothiazide: 50mg/12.5mg, 100mg/25mg
Adult Dosing
- Hypertension: 50mg once daily, may increase to 100mg once daily
- Nephropathy: 50mg once daily, may increase to 100mg once daily
- Heart failure: 25mg once daily, may increase to 150mg once daily
Pediatric Dosing
- Hypertension: 0.7mg/kg once daily, may increase to 1.4mg/kg once daily (6-16 years)
- Nephropathy: Not recommended for pediatric patients
Indications
- Hypertension
- Diabetic nephropathy
- Heart failure
- Left ventricular hypertrophy
Mechanism of Action
- Blocks angiotensin II receptor, decreases vasoconstriction and aldosterone secretion
- Increases sodium excretion, decreases peripheral resistance
Contraindications
- Hypersensitivity to losartan or diuretics
- Anuria or acute kidney injury
- Concomitant use with aliskiren in diabetic patients
Adverse Reactions
- Dizziness
- Headache
- Fatigue
- Cough
- Hyperkalemia
- Hypotension
Drug Interactions
- Potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: increased risk of lithium toxicity
- Warfarin: increased risk of bleeding
- Non-steroidal anti-inflammatory drugs (NSAIDs): decreased renal function
Curated Content: Needs Vetting Before Put to Clinical Use