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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS › Angiotensin II receptor blockers (ARBs) and diuretics
candesartan and diuretics
C09DA06
Forms & Strengths
- Tablets: 4mg/12.5mg, 8mg/12.5mg, 8mg/25mg, 16mg/12.5mg, 16mg/25mg, 32mg/12.5mg, 32mg/25mg
- Capsules or tablets may have different strength combinations
Adult Dosing
- Hypertension: 8-16mg once daily, max 32mg
- Heart failure: 4-8mg once daily, titrate as needed
Pediatric Dosing
- Hypertension (ages 6-18 years): initial dose 4-8mg, max dose 8-16mg
- Not studied in pediatric heart failure
Indications
- Treatment of hypertension
- Treatment of heart failure
Mechanism of Action
- Blocks angiotensin II type 1 receptors
- Inhibits vasoconstriction and aldosterone-mediated volume expansion
Contraindications
- Hypersensitivity to candesartan, diuretics, or sulfonamide
- Anuria or acute kidney injury
- Bilateral renal artery stenosis or unilateral stenosis in a solitary kidney
Adverse Reactions
- Hypotension
- Dizziness
- Headache
- Hyperkalemia
- Renal dysfunction
Drug Interactions
- Potassium supplements or potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: increased risk of lithium toxicity
- Nonsteroidal anti-inflammatory drugs (NSAIDs): decreased antihypertensive effect
Curated Content: Needs Vetting Before Put to Clinical Use