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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS › Angiotensin II receptor blockers (ARBs) and calcium channel blockers
irbesartan and amlodipine
C09DB05
Forms & Strengths
- Tablets: irbesartan 150mg + amlodipine 5mg
- Tablets: irbesartan 300mg + amlodipine 5mg
- Tablets: irbesartan 300mg + amlodipine 10mg
Adult Dosing
- Hypertension: initial dose 150mg/5mg once daily, titrate as needed
- Maximum dose 300mg/10mg once daily
Pediatric Dosing
- Not recommended for patients under 18 years
Indications
- Hypertension, alone or with other antihypertensive agents
Mechanism of Action
- Irbesartan: selective angiotensin II receptor antagonist
- Amlodipine: calcium channel blocker, inhibits L-type calcium channels
Contraindications
- Hypersensitivity to irbesartan, amlodipine, or any component
- Pregnancy, especially 2nd and 3rd trimesters
Adverse Reactions
- Dizziness, headache, edema, fatigue, nausea, cough
- Hypotension, syncope, renal impairment in some patients
Drug Interactions
- Aliskiren: increased risk of hypotension, renal impairment
- Potassium-sparing diuretics: increased risk of hyperkalemia
- CYP3A4 inhibitors: increased amlodipine levels, monitor for hypotension
Curated Content: Needs Vetting Before Put to Clinical Use