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CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS › Angiotensin II receptor blockers (ARBs) and calcium channel blockers
candesartan and amlodipine
C09DB07
Forms & Strengths
- Tablets: 16mg/5mg, 16mg/10mg, 32mg/5mg, 32mg/10mg
- Fixed-dose combination of candesartan and amlodipine
Adult Dosing
- Hypertension: 16mg/5mg to 32mg/10mg orally once daily
- Titrate every 1-2 weeks, max dose 32mg/10mg
- Adjust dose based on patient response
Pediatric Dosing
- Not recommended for pediatric patients under 18 years
- Safety and efficacy not established in pediatric population
Indications
- Treatment of hypertension
- Reduction of risk of cardiovascular morbidity in patients with hypertension
Mechanism of Action
- Candesartan: angiotensin II receptor antagonist, reduces vasoconstriction and aldosterone secretion
- Amlodipine: calcium channel blocker, reduces vascular resistance and blood pressure
Contraindications
- Hypersensitivity to candesartan, amlodipine, or other components
- Pregnancy, especially during 2nd and 3rd trimesters
- Bilateral renal artery stenosis or unilateral stenosis in a single functioning kidney
Adverse Reactions
- Dizziness, headache, back pain, fatigue, peripheral edema
- Hypotension, cough, diarrhea, abdominal pain, nausea
Drug Interactions
- Potassium supplements and potassium-sparing diuretics: increased risk of hyperkalemia
- Lithium: increased risk of lithium toxicity
- Nonsteroidal anti-inflammatory drugs (NSAIDs): decreased antihypertensive effect
Curated Content: Needs Vetting Before Put to Clinical Use