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telmisartan, amlodipine and hydrochlorothiazide

C09DX08

Forms & Strengths

Tablets: 40mg telmisartan/5mg amlodipine/12.5mg hydrochlorothiazide
Tablets: 40mg telmisartan/10mg amlodipine/12.5mg hydrochlorothiazide
Tablets: 80mg telmisartan/5mg amlodipine/12.5mg hydrochlorothiazide
Tablets: 80mg telmisartan/10mg amlodipine/12.5mg hydrochlorothiazide
Tablets: 80mg telmisartan/10mg amlodipine/25mg hydrochlorothiazide

Adult Dosing

Hypertension: 1 tablet orally once daily
May titrate after 1-2 weeks, maximum dose 80mg telmisartan/10mg amlodipine/25mg hydrochlorothiazide
Use lowest dose for black patients or those with Intravascular Volume Depletion

Pediatric Dosing

Not indicated for pediatric patients
Safety and efficacy not established in patients under 18 years old

Indications

Hypertension in patients not adequately controlled with telmisartan and amlodipine or telmisartan and hydrochlorothiazide
Severe hypertension

Mechanism of Action

Telmisartan: Angiotensin II receptor antagonist
Amlodipine: Calcium channel blocker, inhibits L-type calcium channels
Hydrochlorothiazide: Thiazide diuretic, inhibits sodium reabsorption in the kidneys

Contraindications

Anuria or acute kidney injury
Hypersensitivity to telmisartan, amlodipine, hydrochlorothiazide, or other thiazides
Second or third trimester of pregnancy

Adverse Reactions

Hypotension
Dizziness
Headache
Edema
Fatigue
Gastrointestinal disorders
Elevated creatinine and uric acid levels
Hyperkalemia

Drug Interactions

Lithium: Increased risk of lithium toxicity
Aliskiren: Increased risk of hyperkalemia, hypotension, and decreased renal function
Furosemide: Increased risk of hypokalemia
Digoxin: Monitor serum digoxin levels
Atorvastatin: Increased risk of myopathy and rhabdomyolysis

Curated Content: Needs Vetting Before Put to Clinical Use