← Search & browse all drugs
CARDIOVASCULAR SYSTEM › LIPID MODIFYING AGENTS › LIPID MODIFYING AGENTS, PLAIN › HMG CoA reductase inhibitors
atorvastatin
C10AA05
Forms & Strengths
- Tablets: 10mg, 20mg, 40mg, 80mg
- Oral dosage form
Adult Dosing
- Initial dose: 10mg to 20mg once daily
- Maintenance dose: 10mg to 80mg once daily
- Max dose: 80mg/day
Pediatric Dosing
- 10-17 years: 10mg to 20mg once daily
- Limited data for children under 10 years
- Dose adjustment may be needed
Indications
- Hyperlipidemia
- Heterozygous familial hypercholesterolemia
- Homozygous familial hypercholesterolemia
- Primary dysbetalipoproteinemia
- Mixed dyslipidemia
Mechanism of Action
- Inhibits HMG-CoA reductase
- Decreases cholesterol synthesis
- Increases expression of LDL receptors
- Enhances clearance of LDL cholesterol
Contraindications
- Hypersensitivity to atorvastatin
- Active liver disease
- Unexplained elevated liver enzymes
- Pregnancy and breastfeeding
Adverse Reactions
- Headache
- Nausea
- Vomiting
- Abdominal pain
- Constipation
- Myalgia
- Elevated liver enzymes
- Rhabdomyolysis
Drug Interactions
- Cyclosporine increases atorvastatin levels
- Gemfibrozil increases risk of myopathy
- Erythromycin and clarithromycin increase atorvastatin levels
- Warfarin may be potentiated by atorvastatin
- Avoid concomitant use with strong CYP3A4 inhibitors
Curated Content: Needs Vetting Before Put to Clinical Use