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CARDIOVASCULAR SYSTEM › LIPID MODIFYING AGENTS › LIPID MODIFYING AGENTS, PLAIN › Fibrates
clofibrate
C10AB01
Forms & Strengths
- Capsule: 500mg
- Tablet: 500mg
Adult Dosing
- Typical dose: 1000mg twice daily
- Maximum dose: 2000mg daily
Pediatric Dosing
- Not recommended for children under 12 years old
- For children 12 and older: same as adult dosing
Indications
- Hyperlipidemia
- Combined hyperlipidemia
- Hypertriglyceridemia
Mechanism of Action
- Activates peroxisome proliferator-activated receptor alpha (PPAR-alpha)
- Increases lipoprotein lipase activity
- Decreases very-low-density lipoprotein (VLDL) production
Contraindications
- Liver disease
- Kidney disease
- Gallbladder disease
- Breastfeeding
Adverse Reactions
- Gastrointestinal upset
- Headache
- Dizziness
- Increased risk of gallstones
- Myopathy
Drug Interactions
- Increases INR when co-administered with warfarin
- May increase risk of myopathy with statins
- Concomitant use with oral contraceptives may increase risk of thromboembolism
Curated Content: Needs Vetting Before Put to Clinical Use