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CARDIOVASCULAR SYSTEM › LIPID MODIFYING AGENTS › LIPID MODIFYING AGENTS, PLAIN › Nicotinic acid and derivatives
nicofuranose
C10AD03
Forms & Strengths
- Nicofuranose 0.25g tablets
- Nicofuranose 0.5g tablets
Adult Dosing
- Initial dose: 0.25g orally twice daily
- Maximum dose: 0.5g orally twice daily
Pediatric Dosing
- Pediatric use not established
Indications
- Hyperlipidemia
- Hypertriglyceridemia
- Primary hypercholesterolemia
Mechanism of Action
- Activates lipoprotein lipase
- Inhibits VLDL production
- Increases HDL levels
Contraindications
- Hypersensitivity to nicofuranose
- Severe liver dysfunction
- Severe kidney dysfunction
Adverse Reactions
- Gastrointestinal disturbances
- Liver enzyme elevations
- Headache
- Dizziness
Drug Interactions
- Concomitant use with statins may increase risk of myopathy
- Concomitant use with warfarin may increase INR
- Nicofuranose may interact with other lipid-lowering agents
Curated Content: Needs Vetting Before Put to Clinical Use