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CARDIOVASCULAR SYSTEM › LIPID MODIFYING AGENTS › LIPID MODIFYING AGENTS, PLAIN › Nicotinic acid and derivatives
nicotinyl alcohol (pyridylcarbinol)
C10AD05
Forms & Strengths
- Tablets: 200-300mg
- Injection: 50-100mg/mL
Adult Dosing
- 250-500mg orally 2-3 times a day
- 50-100mg intramuscularly or intravenously 1-2 times a day
Pediatric Dosing
- Not established for children under 12 years
- 12-18 years: 125-250mg orally 2-3 times a day
Indications
- Hyperlipidemia
- Atherosclerosis
- Peripheral vascular disease
Mechanism of Action
- Nicotinic acid receptor agonist
- Increases high-density lipoprotein (HDL) and lowers triglycerides
- Vasodilatory effects
Contraindications
- Active peptic ulcer disease
- Hepatic dysfunction
- Severe hypotension
Adverse Reactions
- Flushing
- Gastrointestinal upset
- Headache
- Hypotension
Drug Interactions
- Aspirin: increased risk of bleeding
- Antihypertensives: enhanced hypotensive effect
- Statins: increased risk of myopathy
Curated Content: Needs Vetting Before Put to Clinical Use