← Search & browse all drugs

omega-3-triglycerides incl. other esters and acids

C10AX06

Forms & Strengths

Oral capsules: 1,000 mg
Oral capsules: 1,200 mg
Oral liquid formulations
Injectable lipid emulsions (parenteral nutrition)

Adult Dosing

Hypertriglyceridemia: 2 to 4 g orally daily administered as a single dose or in divided doses
Parenteral nutrition: 1 to 2 g/kg/day IV as part of total parenteral nutrition

Pediatric Dosing

Parenteral nutrition (pediatric/neonatal): 1 to 3 g/kg/day IV
Hypertriglyceridemia: Safety and efficacy not established in pediatric patients

Indications

Adjunct to diet to reduce triglyceride levels in adult patients with severe (>= 500 mg/dL) hypertriglyceridemia
Source of calories and essential fatty acids for parenteral nutrition

Mechanism of Action

Decreases hepatic synthesis and secretion of very low-density lipoproteins (VLDL-TG)
Increases plasma lipoprotein lipase activity
Promotes fatty acid oxidation in the liver
Alters cell membrane fluidity and eicosanoid production

Contraindications

Hypersensitivity to fish, shellfish, or any component of the formulation
Severe hepatic impairment (for specific oral prescription formulations)
Severe disorders of fat metabolism such as pathologic hyperlipemia

Adverse Reactions

Eructation
Dyspepsia
Taste perversion (fishy taste)
Nausea
Diarrhea
Increased risk of bleeding at high doses
Elevated ALT and AST

Drug Interactions

Anticoagulants and antiplatelet agents: May increase the risk of bleeding due to potential additive antiplatelet effects
Statins: Often co-administered safely for mixed dyslipidemia, though monitor for additive myopathy risks rarely

Curated Content: Needs Vetting Before Put to Clinical Use