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bempedoic acid

C10AX15

Forms & Strengths

Tablet: 180mg
Film-coated tablets

Adult Dosing

Initial dose: 180mg once daily
Maximum dose: 180mg once daily
Dose adjustment for patients with hepatic impairment: not necessary

Pediatric Dosing

Safety and efficacy not established in pediatric patients
Not recommended for use in patients under 18 years

Indications

As an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease
To reduce low-density lipoprotein cholesterol (LDL-C) levels

Mechanism of Action

Inhibits ATP-citrate lyase, a key enzyme in the cholesterol biosynthesis pathway
Reduces cholesterol production in the liver

Contraindications

Hypersensitivity to bempedoic acid or any component of the formulation
Severe hepatic impairment

Adverse Reactions

Most common: upper respiratory tract infection, musculoskeletal pain, fatigue, hyperuricemia
Less common: increased serum creatinine, elevated liver enzymes, rash

Drug Interactions

Concomitant use with simvastatin increases risk of myopathy
May increase international normalized ratio (INR) when co-administered with warfarin

Curated Content: Needs Vetting Before Put to Clinical Use