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CARDIOVASCULAR SYSTEM › LIPID MODIFYING AGENTS › LIPID MODIFYING AGENTS, COMBINATIONS › Combinations of various lipid modifying agents
atorvastatin and omega-3 fatty acids
C10BA08
Forms & Strengths
- Tablets: atorvastatin 10-80mg and omega-3 fatty acids 1000-2000mg
- Capsules: atorvastatin 10-80mg and omega-3 fatty acids 500-1000mg
Adult Dosing
- Primary hypercholesterolemia: atorvastatin 10-80mg/day, omega-3 fatty acids 1000-2000mg/day
- Heterozygous familial hypercholesterolemia: atorvastatin 10-80mg/day, omega-3 fatty acids 1000-2000mg/day
- Hypertriglyceridemia: omega-3 fatty acids 2000-4000mg/day
Pediatric Dosing
- Children 10-17 years: atorvastatin 10-20mg/day, omega-3 fatty acids 500-1000mg/day
- Children under 10 years: not recommended
Indications
- Primary hypercholesterolemia
- Heterozygous familial hypercholesterolemia
- Hypertriglyceridemia
- Cardiovascular event reduction in patients with coronary heart disease
Mechanism of Action
- Atorvastatin: HMG-CoA reductase inhibitor, reduces cholesterol synthesis
- Omega-3 fatty acids: triglyceride-lowering effect, anti-inflammatory properties
Contraindications
- Hypersensitivity to atorvastatin or omega-3 fatty acids
- Active liver disease
- Pregnancy and breastfeeding
Adverse Reactions
- Headache
- Myalgia
- Abdominal pain
- Constipation
- Increased liver enzymes
- Fishy aftertaste with omega-3 fatty acids
Drug Interactions
- Cyclosporine: increased atorvastatin levels
- Gemfibrozil: increased risk of myopathy
- Warfarin: increased INR
- Antacids: reduced atorvastatin absorption
Curated Content: Needs Vetting Before Put to Clinical Use