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CARDIOVASCULAR SYSTEM › LIPID MODIFYING AGENTS › LIPID MODIFYING AGENTS, COMBINATIONS › Lipid modifying agents in combination with other drugs
atorvastatin, acetylsalicylic acid and ramipril
C10BX06
Forms & Strengths
- Tablets: atorvastatin 10mg, acetylsalicylic acid 81mg, ramipril 2.5mg
- Tablets: atorvastatin 10mg, acetylsalicylic acid 81mg, ramipril 5mg
- Tablets: atorvastatin 20mg, acetylsalicylic acid 81mg, ramipril 5mg
- Tablets: atorvastatin 20mg, acetylsalicylic acid 81mg, ramipril 10mg
Adult Dosing
- Initial dose: 1 tablet daily, titrate to response
- Maximum dose: atorvastatin 80mg, acetylsalicylic acid 81-100mg, ramipril 10mg daily
- Dosage adjustment for renal impairment: reduce ramipril dose
Pediatric Dosing
- Not recommended for children under 18 years
- Use with caution in pediatric patients with renal impairment
Indications
- Primary and secondary prevention of cardiovascular events
- Stable angina
- Hypertension
- Hyperlipidemia
- Diabetes with cardiovascular risk factors
Mechanism of Action
- Atorvastatin: HMG-CoA reductase inhibitor, reduces cholesterol synthesis
- Acetylsalicylic acid: cyclooxygenase inhibitor, antiplatelet effect
- Ramipril: angiotensin-converting enzyme inhibitor, reduces angiotensin II levels
Contraindications
- Hypersensitivity to atorvastatin, acetylsalicylic acid, or ramipril
- Active liver disease or elevated liver enzymes
- Pregnancy and breastfeeding
- Bilateral renal artery stenosis
Adverse Reactions
- Muscle pain, myalgia, and rhabdomyolysis (atorvastatin)
- Gastrointestinal bleeding, ulcers (acetylsalicylic acid)
- Cough, dizziness, and hyperkalemia (ramipril)
Drug Interactions
- Concomitant use with warfarin, increases bleeding risk
- Interacts with cyclosporine, gemfibrozil, and other statin-interacting drugs
- Concomitant use with ACE inhibitors, increases hyperkalemia risk
- Interaction with diuretics, may increase lithium levels
Curated Content: Needs Vetting Before Put to Clinical Use