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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Antibiotics
natamycin
D01AA02
Adult Dosing
- Fungal keratitis: 1 drop into the conjunctival sac every 1 to 2 hours initially, increased to every 3 to 4 hours after 3 to 4 days; typical duration 14 to 21 days
Pediatric Dosing
- Fungal keratitis (Children ≥ 2 years): 1 drop into the conjunctival sac every 1 to 2 hours initially, tapered as condition improves
Indications
- Treatment of fungal keratitis caused by susceptible organisms including Fusarium solani
Mechanism of Action
- Polyene antifungal that binds to ergosterol in fungal cell membranes, altering cell permeability and causing leakage of intracellular components
Contraindications
- Hypersensitivity to natamycin or any components of the formulation
Adverse Reactions
- Eye irritation
- Eye pain
- Blurred vision
- Hyperemia
- Foreign body sensation
- Allergic reactions
Drug Interactions
- No significant systemic drug-interactions identified due to minimal systemic absorption following topical ophthalmic administration
Curated Content: Needs Vetting Before Put to Clinical Use