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mepartricin

D01AA06

Forms & Strengths

Vaginal suppositories: 25,000 IU
Oral capsules: 10,000 IU
Oral tablets: 10,000 IU

Adult Dosing

Vaginal candidiasis: 1 suppository (25,000 IU) vaginally once daily for 10-20 days
Benign prostatic hyperplasia (oral): 10,000 IU to 30,000 IU daily in divided doses for 2 to 3 months

Pediatric Dosing

Safety and efficacy in pediatric patients have not been established

Indications

Treatment of vaginal candidiasis and other fungal vaginitis
Management of symptoms associated with benign prostatic hyperplasia (BPH)

Mechanism of Action

Polyene macrolide antifungal antibiotic that binds to ergosterol in fungal cell membranes, causing increased permeability, leakage of intracellular components, and cell death
In the context of BPH, binds to cholesterol and lowers prostatic tissue cholesterol and dihydrotestosterone levels, reducing prostatic congestion

Contraindications

Known hypersensitivity to mepartricin or other polyene antimycotics
Severe renal impairment (for oral formulations)

Adverse Reactions

Vaginal irritation, burning, or itching upon insertion
Mild gastrointestinal disturbances (nausea, diarrhea) with oral administration
Allergic skin reactions

Drug Interactions

Antifungal antagonism: possible antagonism with other azole antifungals if used concurrently
Nephrotoxic drugs: increased risk of renal dysfunction with concomitant systemic nephrotoxic agents

Curated Content: Needs Vetting Before Put to Clinical Use