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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
miconazole
D01AC02
Forms & Strengths
- Topical cream 2%
- Topical ointment 2%
- Topical powder 2%
- Vaginal suppository 100mg
- Vaginal suppository 200mg
Adult Dosing
- Apply topical cream/ointment bid for 2-4 weeks
- Insert 1 vaginal suppository 100mg nightly for 7 days
- Insert 1 vaginal suppository 200mg nightly for 3 days
Pediatric Dosing
- Topical: apply cream/ointment bid for 2-4 weeks, for children over 12 years
- Not recommended for children under 12 years for vaginal use
Indications
- Dermatophyte infections
- Cutaneous candidiasis
- Vulvovaginal candidiasis
- Tinea pedis
- Tinea cruris
Mechanism of Action
- Inhibits fungal ergosterol synthesis
- Disrupts cell membrane integrity
- Exhibits antibacterial properties
Contraindications
- Hypersensitivity to imidazoles
- First trimester pregnancy
Adverse Reactions
- Local irritation
- Pruritus
- Burning sensation
- Hypersensitivity reactions
- Vulvar itching or burning
Drug Interactions
- Warfarin: increased anticoagulant effect
- Oral antidiabetics: increased hypoglycemic effect
- CYP3A4 inhibitors: increased miconazole levels
Curated Content: Needs Vetting Before Put to Clinical Use