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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
econazole
D01AC03
Forms & Strengths
- Topical nitrate antifungal
- Econazole nitrate cream 1%
- Econazole nitrate foam 1%
Adult Dosing
- Tinea pedis, tinea cruris, tinea corporis: Apply a sufficient amount to cover affected areas once daily for 2 weeks
- Cutaneous candidiasis: Apply a sufficient amount to cover affected areas once daily for 2 weeks
- Tinea versicolor: Apply to affected areas once daily for 2 weeks
- Vulvovaginal candidiasis (when applicable by formulation): 1 vaginal suppository (150 mg) daily for 3 days or cream applied intravaginally
Pediatric Dosing
- Safety and efficacy not established in pediatric patients under 12 years of age for topical formulations
- Adolescents (12-17 years): Same dosage as adults for topical fungal infections
Indications
- Treatment of tinea pedis (athlete's foot)
- Treatment of tinea cruris (jock itch)
- Treatment of tinea corporis (ringworm)
- Treatment of cutaneous candidiasis
- Treatment of tinea versicolor (pityriasis versicolor)
Mechanism of Action
- Broad-spectrum imidazole antifungal agent
- Inhibits fungal cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase
- Blocks conversion of lanosterol to ergosterol, essential fungal cell membrane component
- Leads to increased fungal membrane permeability, leakage of cellular contents, and cell lysis
Contraindications
- Hypersensitivity to econazole, other imidazole antifungals, or any component of the formulation
Adverse Reactions
- Burning
- Stinging
- Pruritus
- Erythema
- Irritation
- Contact dermatitis
Drug Interactions
- Topical absorption is minimal, resulting in very low systemic drug interactions
- Potential for antagonism with systemic antifungals (theoretical)
- May weaken latex condoms and diaphragms (vaginal formulations)
Curated Content: Needs Vetting Before Put to Clinical Use