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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
chlormidazole
D01AC04
Forms & Strengths
- cream 1%
- lotion 1%
- powder 1%
Adult Dosing
- apply 1% cream or lotion bid for 4 weeks
- use 1% powder bid for 4 weeks
Pediatric Dosing
- apply 1% cream or lotion bid for 4 weeks in children over 3 years
Indications
- treatment of fungal infections
- seborrheic dermatitis
- pityriasis versicolor
Mechanism of Action
- inhibits fungal ergosterol synthesis
- disrupts cell membrane integrity
Contraindications
- hypersensitivity to imidazoles
- pregnancy (1st trimester)
Adverse Reactions
- local irritation
- pruritus
- erythema
- stinging sensation
Drug Interactions
- increased risk of hepatotoxicity with disulfiram
- concurrent use with warfarin may increase INR
Curated Content: Needs Vetting Before Put to Clinical Use