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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
oxiconazole
D01AC11
Adult Dosing
- Tinea pedis: Apply to affected and surrounding skin areas twice daily for 1 month
- Tinea cruris and tinea corporis: Apply once to twice daily for 2 weeks
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
Indications
- Topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum
Mechanism of Action
- Azole antifungal that inhibits lanosterol 14-alpha-demethylase, decreasing ergosterol synthesis and causing increased fungal cell membrane permeability
Contraindications
- Hypersensitivity to oxiconazole or any component of the formulation
Adverse Reactions
- Pruritus
- Burning
- Irritation
- Erythema
- Fissuring
- Maceration
Drug Interactions
- No significant systemic drug interactions identified due to minimal percutaneous absorption
Curated Content: Needs Vetting Before Put to Clinical Use