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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
sertaconazole
D01AC14
Adult Dosing
- Tinea pedis: Apply to affected area and immediate surrounding skin twice daily for 4 weeks
Pediatric Dosing
- Safety and efficacy not established in pediatric patients < 12 years
Indications
- Topical treatment of interdigital tinea pedis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum in immunocompetent patients >= 12 years
Mechanism of Action
- Broad-spectrum imidazole antifungal that inhibits fungal cytochrome P450-dependent 14 alpha-demethylase, decreasing ergosterol synthesis and increasing fungal cell membrane permeability
Contraindications
- Hypersensitivity to sertaconazole or any component of the formulation
Adverse Reactions
- Contact dermatitis
- Dry skin
- Application site burning or stinging
- Skin tenderness
Drug Interactions
- No formal drug interaction studies performed due to minimal systemic absorption following topical application
Curated Content: Needs Vetting Before Put to Clinical Use