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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
imidazoles/triazoles in combination with corticosteroids
D01AC20
Forms & Strengths
- Clotrimazole 1% + Betamethasone dipropionate 0.05% cream
- Clotrimazole 1% + Betamethasone dipropionate 0.05% lotion
- Miconazole 2% + Hydrocortisone 1% cream
Adult Dosing
- Apply a thin layer to affected area twice daily for 2-4 weeks
- For severe infections, apply once daily for 2-4 weeks
Pediatric Dosing
- Apply a thin layer to affected area twice daily for 2-4 weeks in children over 12 years
- For children under 12 years, use with caution and under medical supervision
Indications
- Treatment of fungal infections complicated by inflammation
- Dermatomycoses, such as tinea corporis, tinea cruris, and tinea pedis
- Cutaneous candidiasis
Mechanism of Action
- Imidazoles/triazoles inhibit fungal ergosterol synthesis, disrupting cell membrane function
- Corticosteroids reduce inflammation and suppress allergic reactions
Contraindications
- Hypersensitivity to imidazoles/triazoles or corticosteroids
- Untreated vaginal moniliasis
- Tuberculosis of the skin
Adverse Reactions
- Skin irritation, such as redness, itching, or burning
- Allergic contact dermatitis
- Adrenal suppression with prolonged use
Drug Interactions
- Increased risk of adrenal suppression with concurrent use of other corticosteroids
- Inhibition of CYP3A4 by imidazoles/triazoles may increase levels of other drugs metabolized by this enzyme
Curated Content: Needs Vetting Before Put to Clinical Use