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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Imidazole and triazole derivatives
neticonazole
D01AC21
Forms & Strengths
- Topical cream 1%
- Topical solution 1%
Adult Dosing
- Tinea pedis: Apply to affected area once daily for 2 weeks
- Tinea cruris and tinea corporis: Apply once daily for 2 to 4 weeks
Pediatric Dosing
- Safety and efficacy in pediatric patients not established; use with caution
Indications
- Topical treatment of superficial dermatophyte infections
- Tinea pedis (athlete's foot)
- Tinea cruris (jock itch)
- Tinea corporis (ringworm)
Mechanism of Action
- Imidazole antifungal agent
- Inhibits lanosterol 14-alpha-demethylase, disrupting fungal ergosterol synthesis
- Leads to increased fungal cell membrane permeability and cell lysis
Contraindications
- Hypersensitivity to neticonazole, other imidazole antifungals, or any component of the formulation
Adverse Reactions
- Application site erythema
- Pruritus
- Burning or stinging sensation
- Contact dermatitis
Drug Interactions
- Systemic absorption is minimal following topical application; significant pharmacokinetic drug interactions are unlikely
Curated Content: Needs Vetting Before Put to Clinical Use