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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Other antifungals for topical use
bromochlorosalicylanilide
D01AE01
Forms & Strengths
- Topical cream/ointment: concentrations vary by regional formulation
Adult Dosing
- Apply thinly to affected skin areas 1 to 2 times daily
- Duration of therapy typically 2 to 4 weeks depending on clinical response
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established
- Use with caution and limit application area if prescribed
Indications
- Treatment of superficial fungal skin infections (dermatophytosis)
- Adjuvant treatment of cutaneous candidiasis and tinea versicolor
Mechanism of Action
- Halogenated salicylanilide derivative with antifungal and antibacterial properties
- Disrupts fungal cell membrane integrity and inhibits cellular metabolism
Contraindications
- Hypersensitivity to bromochlorosalicylanilide or other halogenated salicylanilides
- Application to broken, denuded, or severely inflamed skin
- Ophthalmic use
Adverse Reactions
- Local skin irritation, burning, or stinging at application site
- Contact dermatitis and photosensitivity reactions
- Erythema and pruritus
Drug Interactions
- Concurrent use of other topical irritants or keratolytics may increase skin irritation
- Potential for cross-sensitization with other halogenated salicylanilides and related compounds
Curated Content: Needs Vetting Before Put to Clinical Use