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DERMATOLOGICALS › ANTIFUNGALS FOR DERMATOLOGICAL USE › ANTIFUNGALS FOR TOPICAL USE › Other antifungals for topical use
polynoxylin
D01AE05
Forms & Strengths
- Gel: 2%
- Lozenge/Pastille: 10 mg
- Dental Paste: 5%
Adult Dosing
- Oral candidiasis/stomatitis: Dissolve 1 lozenge in the mouth 4 to 6 times daily.
- Skin and mucosal fungal/bacterial infections: Apply gel or paste to the affected area 2 to 3 times daily.
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established; use with caution and dose adjusted by age for topical or oral local applications.
Indications
- Treatment of superficial fungal infections of the skin and mucous membranes
- Oral candidiasis and stomatitis
- Minor dental and gingival infections
Mechanism of Action
- Condensation product of formaldehyde and urea acting as an antiseptic and disinfectant.
- Exerts antimicrobial and antifungal activity through the slow, sustained release of formaldehyde at the site of infection.
Contraindications
- Hypersensitivity to polynoxylin, formaldehyde, or urea
- Severe inflammatory skin conditions where high systemic absorption is possible
Adverse Reactions
- Local skin irritation
- Contact dermatitis
- Burning sensation upon application
- Allergic hypersensitivity reactions
Drug Interactions
- No major systemic drug-interactions documented due to primarily topical and localized action.
- Avoid concurrent use of other topical antiseptic agents on the exact same site to prevent excessive irritation.
Curated Content: Needs Vetting Before Put to Clinical Use