← Search & browse all drugs
DERMATOLOGICALS › EMOLLIENTS AND PROTECTIVES › PROTECTIVES AGAINST UV-RADIATION › Protectives against UV-radiation for topical use
octinoxate
D02BA02
Forms & Strengths
- Topical cream/lotion/gel: variable concentrations (typically 2% to 7.5% as a UV filter)
- Combination formulations: broad-spectrum sunscreens, moisturizers, and cosmetics with SPF
Adult Dosing
- Topical sunscreen: Apply generously and evenly to all exposed skin 15 to 30 minutes before sun exposure
- Reapplication: Reapply at least every 2 hours, or after 40 to 80 minutes of swimming or sweating, and immediately after towel drying
Pediatric Dosing
- Children under 6 months: Consult a physician before use
- Children 6 months and older: Apply generously and evenly to exposed skin; follow same reapplication schedule as adults
Indications
- Prevention of sunburn
- Reduction of the risk of skin aging and skin cancer caused by UV exposure
- Broad-spectrum UV-B radiation absorption
Mechanism of Action
- Organic UV filter (chemical sunscreen agent)
- Absorbs and converts harmful ultraviolet B (UVB) radiation (wavelengths 290-320 nm) into thermal energy, preventing penetration into the epidermis
Contraindications
- Hypersensitivity to octinoxate or any components of the formulation
- Application on broken, damaged, or infected skin
Adverse Reactions
- Local skin irritation, burning, or stinging
- Contact dermatitis and allergic skin reactions
- Pruritus and erythema at the site of application
Drug Interactions
- May enhance the percutaneous absorption of certain topical medications (e.g., insect repellents, topical corticosteroids)
- Potential for increased systemic absorption when applied concurrently with other chemical sunscreens or penetration enhancers
Curated Content: Needs Vetting Before Put to Clinical Use