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DERMATOLOGICALS › PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS › CICATRIZANTS › Other cicatrizants
crilanomer
D03AX09
Adult Dosing
- Apply thin layer to affected skin areas 2 to 3 times daily
- Duration of treatment depends on clinical response
Pediatric Dosing
- Safety and efficacy in pediatric patients not established
Indications
- Treatment of cutaneous ulcers
- Promotion of wound healing in chronic skin lesions
Mechanism of Action
- Proteolytic enzyme preparation that aids in debridement of necrotic tissue
- Stimulates granulation and epithelialization in wound healing
Contraindications
- Known hypersensitivity to crilanomer or any component of the formulation
- Do not use on severe, extensive burns
Adverse Reactions
- Local irritation at application site
- Transient stinging or burning sensation
- Allergic contact dermatitis
Drug Interactions
- Avoid concurrent use with topical heavy metal antiseptics (e.g., silver, mercury) which may inactivate the enzymatic activity
- No significant systemic drug interactions anticipated due to minimal percutaneous absorption
Curated Content: Needs Vetting Before Put to Clinical Use