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DERMATOLOGICALS › PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS › CICATRIZANTS › Other cicatrizants
Betulae cortex
D03AX13
Forms & Strengths
- Topical ointment: 10% extract from birch bark (Betulae cortex)
- Medicated wound gel containing triterpenes from birch bark
Adult Dosing
- Apply a thin layer to the affected skin area 3 to 4 times daily
- Can be applied under sterile dressings as required
- Use continuously until the wound is healed or for a maximum of 4 weeks
Pediatric Dosing
- Safe and effective in pediatric patients from newborn (term infants) upwards
- Apply a thin layer to the affected skin area 3 to 4 times daily
- Duration of use in children should not exceed 4 weeks per treatment course
Indications
- Treatment of partial thickness wounds in adults and children
- Promotion of healing in superficial, acute wounds such as minor burns and abrasions
Mechanism of Action
- Triterpenes (such as betulin, betulinic acid, lupeol, oleanolic acid) stimulate keratinocyte migration and proliferation
- Accelerates re-epithelialization of partial-thickness wounds
- Exerts anti-inflammatory effects by modulating cytokine release in wound tissue
Contraindications
- Hypersensitivity to birch bark preparations or any excipients in the formulation
- Application to infected or heavily exudative wounds without prior antimicrobial treatment
Adverse Reactions
- Local application site reactions (pruritus, burning, erythema)
- Contact dermatitis or allergic skin reactions in sensitive individuals
Drug Interactions
- No formal drug-interaction studies have been performed
- Avoid simultaneous topical application of other irritating agents or keratolytics on the same treatment area
Curated Content: Needs Vetting Before Put to Clinical Use