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DERMATOLOGICALS › PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS › CICATRIZANTS › Other cicatrizants
Centella asiatica herba, incl. combinations
D03AX14
Forms & Strengths
- Ointment: 1%
- Cream: 1%
- Topical powder: 0.1%
Adult Dosing
- Apply thinly to affected area 1 to 3 times daily
- Duration of treatment typically up to several weeks depending on healing progress
Pediatric Dosing
- Safety and efficacy in children not formally established; use with caution
Indications
- Promotion of wound healing in minor cuts, abrasions, and burns
- Treatment of chronic ulcers, bedsores, and surgical scars
- Adjunct in venous insufficiency-related skin conditions
Mechanism of Action
- Triterpenes (asiaticoside, madecassoside) stimulate collagen synthesis
- Promotes angiogenesis and microcirculation in the wound bed
- Modulates inflammatory response and enhances epithelialization
Contraindications
- Known hypersensitivity to Centella asiatica or related plant species
- Application on deep puncture wounds, severe burns, or infected lesions without medical supervision
Adverse Reactions
- Allergic contact dermatitis
- Local skin irritation, redness, or pruritus
- Burning sensation upon application
Drug Interactions
- No significant systemic drug interactions documented with topical use
- Potential additive irritant effects with other topical keratolytics or drying agents
Curated Content: Needs Vetting Before Put to Clinical Use