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DERMATOLOGICALS › PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS › ENZYMES › Proteolytic enzymes
collagenase
D03BA02
Adult Dosing
- Apply a thin layer of ointment to the lesion once daily (or up to twice daily as directed by physician).
- Continue treatment until complete removal of necrotic tissue is achieved.
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established.
Indications
- Debridement of chronic dermal ulcers and severely burned areas.
Mechanism of Action
- Enzymatic debriding agent derived from Clostridium histolyticum.
- Selectively digests collagen in necrotic tissue without affecting healthy granulation tissue.
Contraindications
- Known hypersensitivity to collagenase or any component of the preparation.
- Systemic or localized hypersensitivity reactions.
Adverse Reactions
- Transient local burning or pain at the application site
- Erythema
- Hypersensitivity reactions
Drug Interactions
- Avoid concurrent use with heavy metal-containing antiseptics (e.g., silver, mercury, iodine) as they may inactive the enzyme.
- Avoid detergents and enzymatic cleansers that may interfere with collagenase activity.
Curated Content: Needs Vetting Before Put to Clinical Use