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DERMATOLOGICALS › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › Antihistamines for topical use
chloropyramine
D04AA09
Forms & Strengths
- Tablets: 25mg, 50mg, 100mg
- Syrup: 20mg/5ml
- Injectable: 20mg/ml
Adult Dosing
- Allergic reactions: 25mg to 50mg orally every 4 to 6 hours
- Pruritus: 25mg to 50mg orally every 4 to 6 hours
- Urticaria: 25mg to 50mg orally every 4 to 6 hours
- Maximum dose: 200mg per day
Pediatric Dosing
- Children over 12 years: same as adult dose
- Children 6-12 years: 12.5mg to 25mg orally every 4 to 6 hours
- Children under 6 years: not recommended
Indications
- Allergic reactions
- Pruritus
- Urticaria
- Anaphylaxis
- Angioedema
Mechanism of Action
- Competitively blocks histamine H1 receptors
- Decreases allergic response by inhibiting histamine-mediated vasodilation
- Inhibits release of histamine and other mediators from mast cells
Contraindications
- Hypersensitivity to chloropyramine or other antihistamines
- Narrow-angle glaucoma
- Prostatic hypertrophy
- Obstructive urinary disorders
- Porphyria
Adverse Reactions
- Drowsiness
- Dizziness
- Headache
- Dry mouth
- Gastrointestinal upset
- Urinary retention
- Palpitations
- Hypotension
Drug Interactions
- MAOIs: increased risk of hypertensive crisis
- Sedatives: additive CNS depression
- Anticholinergics: enhanced anticholinergic effects
- Sympathomimetics: decreased efficacy of sympathomimetics
Curated Content: Needs Vetting Before Put to Clinical Use