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DERMATOLOGICALS › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › Antihistamines for topical use
isothipendyl
D04AA22
Forms & Strengths
- Topical cream: 0.75%
- Topical ointment: 0.75%
Adult Dosing
- Apply a thin layer to the affected area 2 to 3 times daily
- Limit use to small skin areas
Pediatric Dosing
- Safety and efficacy not well established in infants
- Use with caution in children; avoid large surface areas
Indications
- Symptomatic relief of pruritus
- Allergic skin conditions
- Insect bites
- Eczema with secondary itching
Mechanism of Action
- Competitive H1-receptor antagonist
- Blocks histamine-induced pruritus, vasodilation, and increased vascular permeability in the skin
- Possesses mild local anesthetic and anticholinergic properties
Contraindications
- Hypersensitivity to isothipendyl or other phenothiazine derivatives
- Application to oozing, blistered, or broken skin
- Use in or near the eyes or mucous membranes
Adverse Reactions
- Local skin irritation
- Contact dermatitis
- Erythema
- Photosensitivity reactions upon sun exposure
Drug Interactions
- None notable with topical application due to minimal systemic absorption
- Potential additive local irritant effects when used concurrently with other topical therapies on the same skin site
Curated Content: Needs Vetting Before Put to Clinical Use